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TRISH launched the Enhancing eXploration Platforms and ANalog Definition (EXPAND), the first-of-its-kind research program to study human health and performance in private spaceflight participants. TRISH’s EXPAND Program collects pre-, in-, and post-flight data from private spaceflight missions and houses it in a centralized database. This request for proposals primarily seeks invasive solutions for real-time ICP measurement in commercial spaceflight participants during spaceflight. Secondarily, proposals must include non-invasive ICP estimation techniques to benchmark against existing methods with the goal of understanding their validity. Funded projects will be divided into two phases. The first phase, the “Flight Definition Phase,” will consist of preparation for a potential flight. The second phase, the “Flight Implementation Phase,” will provide support before, during, and after a specific flight has been identified.